Single Biggest Cancer Dictionary in the World
What is FLT3 inhibitor FF-10101 succinate?
Pronunciation: /flt* θri ˌɪnˈhɪbətər ff* tɛn ˈθaʊzənd, wən ˈhənərd ənd wən succinate*/
FLT3 inhibitor FF-10101 succinate
Definition
The succinate salt form of FF-10101, a FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) inhibitor, with potential antineoplastic activity. Upon administration of FLT3 inhibitor FF-10101 succinate (FF-10101-01), FF-10101 irreversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias.