Single Biggest Cancer Dictionary in the World
What is
etoposide phosphate
?Pronunciation: /etoposide* ˈfɑsfeɪt/
etoposide phosphate
Definition
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent.