Single Biggest Cancer Dictionary in the World

What is

enteric-coated TRPM8 agonist D-3263 hydrochloride

?

Pronunciation: /enteric* ˈkoʊtɪd trpm* eɪt ˈægənɪst di θri ˈθaʊzənd, tu ˈhənərd ənd sixty-three* hydrochloride*/

enteric-coated TRPM8 agonist D-3263 hydrochloride

Definition

An enteric-coated orally bioavailable formulation of the hydrochloride salt of a small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer.