Single Biggest Cancer Dictionary in the World
What is
EGFR inhibitor ABT-414
?Pronunciation: /egfr* ˌɪnˈhɪbətər ˈeɪˈbiˈti fɔr ˈhənərd ənd ˌfɔrˈtin/
EGFR inhibitor ABT-414
Definition
An epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon intravenous infusion, ABT-414 inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase overexpressed in certain tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.