Definition

An extended release (ER) formulation composed of the hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic, in a biodegradable, polymer-lipid encapsulation matrix (PLEX), with antimicrobial activity. Following reconstitution and administration in the surgical wound/incision, doxycycline is released from the matrix over an extended period of time. Upon release, doxycycline reversibly binds to the bacterial 30S ribosomal subunit, and blocks the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of bacterial protein synthesis. This may prevent surgical site infections.