Single Biggest Cancer Dictionary in the World

What is

DNAJB1/PRKACA fusion protein

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Pronunciation: /dnajb* wən prkaca* fˈjuʒən ˈproʊˌtin/

DNAJB1/PRKACA fusion protein

Definition

A fusion protein that is encoded by the DNAJB1/PRKACA fusion gene. This protein contains the N-terminus of DnaJ homolog subfamily B member 1 protein fused to almost the entire cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) protein. The chimeric protein lacks the PKA C-alpha domains that interact with PKA regulatory subunits.