Single Biggest Cancer Dictionary in the World
What is
DNAJB1/PRKACA fusion protein
?Pronunciation: /dnajb* wən prkaca* fˈjuʒən ˈproʊˌtin/
DNAJB1/PRKACA fusion protein
Definition
A fusion protein that is encoded by the DNAJB1/PRKACA fusion gene. This protein contains the N-terminus of DnaJ homolog subfamily B member 1 protein fused to almost the entire cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) protein. The chimeric protein lacks the PKA C-alpha domains that interact with PKA regulatory subunits.