Single Biggest Cancer Dictionary in the World
What is
dactinomycin
?Pronunciation: /dactinomycin*/
dactinomycin
Definition
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.