Definition

An orally bioavailable botanically-based formulation containing multiple polyphenols, including curcumin, the polyphenol derived from the plant Curcuma longa that is also known as turmeric, with potential anti-inflammatory, immunomodulatory and antineoplastic activities. Upon oral administration of curcumin/polyphenols-containing botanical agent APG-157, the curcumin and polyphenols in APG-157 may exert anti-inflammatory activity by decreasing the production of inflammation mediators, such as interleukin (IL) 1-beta, IL-6 and IL-8. The curcumin and polyphenols may also promote T-cell recruitment to the tumor microenvironment (TME) and cytotoxic effects against cancer cells.