Single Biggest Cancer Dictionary in the World

What is

cFMS tyrosine kinase inhibitor ARRY-382

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Pronunciation: /cfms* tyrosine* kinase* ˌɪnˈhɪbətər arry* θri ˈhənərd ənd eighty-two*/

cFMS tyrosine kinase inhibitor ARRY-382

Definition

A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.