Single Biggest Cancer Dictionary in the World

What is CENP-E inhibitor GSK-923295A?

Pronunciation: /cenp* i ˌɪnˈhɪbətər gsk* naɪn ˈhənərd ənd tˈwɛntiθˌri ˈθaʊzənd, tu ˈhənərd ənd ninety-five* ə/

CENP-E inhibitor GSK-923295A

Definition

A small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295A binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated mitotic kinesin, plays an essential role in chromosome movement during mitosis and regulates cell-cycle transition from metaphase to anaphase.