Single Biggest Cancer Dictionary in the World
What is CD8-depleted non-engrafting HLA-mismatched unrelated donor lymphocytes?
Pronunciation: /ˈsiˈdi eɪt dɪˈplitɪd nɑn engrafting* hla* mɪsˈmæʧt ˌənrɪˈleɪtɪd ˈdoʊnər ˈlɪmfəˌsaɪts/
CD8-depleted non-engrafting HLA-mismatched unrelated donor lymphocytes
Definition
A preparation of allogeneic lymphocytes from an HLA-mismatched donor that have been selectively depleted of CD8+ T cells, with potential T-cell reconstitution purposes. Upon infusion, the donor-derived CD8+-depleted lymphocytes may increase the levels of CD4+ T cells (Teffs) and promote T-cell reconstitution. The infusion of donor lymphocytes depleted of CD8 T cells may reduce the risk of inducing graft-versus-host disease (GVHD) compared to the infusion of non-CD8-depleted T cells.