Single Biggest Cancer Dictionary in the World
What is CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes?
Pronunciation: /ˈsiˈdi thirty-three* spɪˈsɪfɪk kɑr lentiviral* ˈvɛktər transduced* autologous* ti ˈlɪmfəˌsaɪts/
CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes
Definition
Autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.