Definition

A radioconjugate composed of AZ14193391, a central nervous system (CNS) penetrant and selective inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon administration, carbon C 11 AZ14193391 specifically targets and binds to PARP1. Upon PET imaging, this radioligand may allow for the assessment of PARP1 expression in tumors and visualization of AZ14193391. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks and double-strand breaks (DSBs).