Definition

An extract from the flowering top of Cannabis sativa, which contains a variety of cannabinoids such as tetrahydrocannabinol (THC), with potential anti-cachexic, muscle relaxing and analgesic activities. Upon administration, the cannabinoids bind to the cannabinoid G-protein coupled receptor CB1, which is located in both central and peripheral neurons. CB1 receptor activation inhibits adenyl cyclase, increases various signal transduction pathways, and modulates the activity of various ion channels. This provides an analgesic effect, may prevent muscle spasms, and may increase appetite.