Single Biggest Cancer Dictionary in the World
What is bismuth Bi213 monoclonal antibody M195?
Pronunciation: /ˈbɪzməθ baɪ tu ˈhənərd ənd ˈθərˈtin ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi ɛm wən ˈhənərd ənd ninety-five*/
bismuth Bi213 monoclonal antibody M195
Definition
A radioimmunoconjugate consisting of murine monoclonal antibody (M195) and bismuth 213 (Bi213). Monoclonal antibody M195 binds to CD33, a surface antigen expressed by myelogenous leukemia cells. Bismuth 213 is an isotope that emits short-ranged high-energy alpha particles. This radioimmunoconjugate selectively delivers alpha particle-mediated cytotoxicity to leukemic cells, thereby limiting the exposure of normal tissues to ionizing radiation.