Single Biggest Cancer Dictionary in the World
What is
beta-thioguanine deoxyriboside
?Pronunciation: /ˈbeɪtə thioguanine* deoxyriboside*/
beta-thioguanine deoxyriboside
Definition
A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells.