Single Biggest Cancer Dictionary in the World
What is
Bcl-2 inhibitor LOXO-338
?Pronunciation: /bcl* tu ˌɪnˈhɪbətər loxo* θri ˈhənərd ənd thirty-eight*/
Bcl-2 inhibitor LOXO-338
Definition
An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, Bcl-2 inhibitor LOXO-338 targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.