Single Biggest Cancer Dictionary in the World
What is B-Raf/VEGFR-2 inhibitor RAF265?
Pronunciation: /bi ræf vegfr* tu ˌɪnˈhɪbətər ræf tu ˈhənərd ənd sixty-five*/
B-Raf/VEGFR-2 inhibitor RAF265
Definition
An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.