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What is Autologous Renal Cell Carcinoma Tumor Lysate-Pulsed Dendritic Cell Vaccine?
Pronunciation: /autologous* ˈrinəl sɛl ˌkɑrsəˈnoʊmə ˈtumər lysate* pulsed* dɛnˈdrɪtɪk sɛl ˌvækˈsin/
Autologous Renal Cell Carcinoma Tumor Lysate-Pulsed Dendritic Cell Vaccine
Definition
A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with renal cell carcinoma (RCC) tumor cell lysate containing tumor associated antigens (TAAs) with potential immunostimulatory and antineoplastic activities. Upon administration, autologous renal cell carcinoma tumor lysate-dendritic cell vaccine may stimulate anti-tumoral cytotoxic T-lymphocyte (CTL) and antibody responses against RCC tumor cells expressing RCC TAAs, resulting in RCC tumor cell lysis.