Definition

A preparation of autologous T cells targeting multiple antigens expressed by melanoma cells, with potential immunomodulating and antineoplastic activities. Peripheral blood T cells from the patient are collected, processed with artificial antigen-presenting scaffolds, and enriched and expanded ex-vivo to generate multiple antigen-specific endogenously-derived T cells (MASE-T) targeting multiple antigens expressed by melanoma cells. Upon administration, the autologous multiple antigen-specific T cells MASE-T are re-introduced into the patient, where they target and kill melanoma cells expressing these specific antigens.