Single Biggest Cancer Dictionary in the World
What is autologous heat-shock protein 70 peptide vaccine AG-858?
Pronunciation: /autologous* hit ʃɑk ˈproʊˌtin ˈsɛvənti ˈpɛpˌtaɪd ˌvækˈsin ˈeɪˈgi eɪt ˈhənərd ənd fifty-eight*/
autologous heat-shock protein 70 peptide vaccine AG-858
Definition
A recombinant cancer vaccine made with tumor-derived heat shock protein 70 (HSP70) peptide complexes. HSP70 associates with antigenic peptides, transporting them into antigen presenting cells (APC) for processing. Tumor-derived HSP70-peptide complexes used in vaccine preparations have been shown to prime tumor immunity and tumor-specific T cells in animal models.