Single Biggest Cancer Dictionary in the World
What is autologous GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes?
Pronunciation: /autologous* gpc* θri ny* eso* wən afp* spɪˈsɪfɪk ˈsiˈdi eɪt ˈpɑzətɪv ti ˈlɪmfəˌsaɪts/
autologous GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes
Definition
A preparation of autologous CD8-positive T lymphocytes that are exposed, ex vivo, to multiple specific hepatocellular carcinoma (HCC) antigens, including glypican (GPC)-3, New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and alpha-fetoprotein (AFP), with potential immunostimulating and antineoplastic activities. Upon infusion of the GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes, the T cells specifically target and lyse cells expressing the targeted HCC neoantigens.