Single Biggest Cancer Dictionary in the World

What is

autologous GM-CSF-secreting lethally irradiated pancreatic cancer vaccine

?

Pronunciation: /autologous* gm* csf* secreting* lethally* ˌɪˈreɪdiˌeɪtɪd ˌpænkriˈætɪk ˈkænsər ˌvækˈsin/

autologous GM-CSF-secreting lethally irradiated pancreatic cancer vaccine

Definition

An irradiated, autologous pancreatic cancer vaccine consisting of patient-specific pancreatic cancer cells genetically modified to secrete the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon vaccination, GVAX pancreatic cancer vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body’s immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B and T cells. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.