Single Biggest Cancer Dictionary in the World

What is

autologous CRISPR-edited tumor infiltrating lymphocytes GT316

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Pronunciation: /autologous* crispr* ˈɛdɪtɪd ˈtumər ˌɪnˈfɪlˌtreɪtɪŋ ˈlɪmfəˌsaɪts gt* θri ˈhənərd ənd ˈsɪkˈstin/

autologous CRISPR-edited tumor infiltrating lymphocytes GT316

Definition

A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from each patient’s resected tumor and edited with the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to eliminate the expression of as of yet not elucidated immunoregulatory targets, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, autologous CRISPR-edited TILs GT316 specifically recognize and kill the patient’s tumor cells. The knockout of the immunoregulatory targets may enhance the proliferation and cytokine release of the TILs.