Definition

Autologous CD8 T lymphocytes against melanoma-associated antigens, with potential immunomodulating and antineoplastic activities. Following leukapheresis and the ex vivo expansion of cytotoxic T-lymphocytes, the autologous CD8+ melanoma-specific T cells are re-introduced into the melanoma patient. These cytotoxic T-cells recognize and kill the patient’s own melanoma cells.