Single Biggest Cancer Dictionary in the World
What is autologous CD19 CAR-expressing CD4+/CD8+ T cells MB-CART19.1?
Pronunciation: /autologous* ˈsiˈdi ˈnaɪnˈtin kɑr ɪkˈsprɛsɪŋ ˈsiˈdi fɔr ˈsiˈdi eɪt ti sɛlz mb* kɑrt ˈnaɪnˈtin wən/
autologous CD19 CAR-expressing CD4+/CD8+ T cells MB-CART19.1
Definition
A preparation of CD4+ and CD8+ autologous T lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4+/CD8+ T cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.