Single Biggest Cancer Dictionary in the World

What is

autologous anti-CD19 CAR-expressing T lymphocytes IC19/1563

?

Pronunciation: /autologous* ˈænˌti ˈsiˈdi ˈnaɪnˈtin kɑr ɪkˈsprɛsɪŋ ti ˈlɪmfəˌsaɪts ic* ˈnaɪnˈtin wən ˈθaʊzənd, faɪv ˈhənərd ənd sixty-three*/

autologous anti-CD19 CAR-expressing T lymphocytes IC19/1563

Definition

A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T lymphocytes IC19/1563 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies.