Single Biggest Cancer Dictionary in the World
What is astatine At 211 anti-CD38 monoclonal antibody OKT10-B10?
Pronunciation: /astatine* æt tu ˈhənərd ənd ˈilɛvən ˈænˌti ˈsiˈdi thirty-eight* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi okt* tɛn bi tɛn/
astatine At 211 anti-CD38 monoclonal antibody OKT10-B10
Definition
A radioimmunoconjugate composed of the anti-CD38 monoclonal antibody (MoAb) OKT10-B10 labeled with the alpha-emitting radionuclide astatine (At) 211 (211At), with potential antineoplastic activity. Upon administration of astatine At 211 anti-CD38 MoAb OKT10-B10, the MoAb moiety targets and binds to CD38-expressing tumor cells, thereby delivering a cytotoxic dose of alpha radiation directly to the CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein and tumor-associated antigen (TAA), is present on various immune cells and in hematologic malignancies; its expression has been correlated with poor prognosis.