Single Biggest Cancer Dictionary in the World
What is AR antagonist BMS-641988?
Pronunciation: /ɑr ænˈtægənəst bms* sɪks ˈhənərd ənd forty-one* ˈθaʊzənd, naɪn ˈhənərd ənd eighty-eight*/
AR antagonist BMS-641988
Definition
An androgen receptor (AR) antagonist with potential antineoplastic and anti-androgenic activities. BMS-641988 binds to the androgen receptor in target tissues, thereby preventing androgen-induced receptor activation, and facilitates the formation of inactive complexes that cannot be translocated to the nucleus. This may inhibit androgen-dependent gene expression, subsequently leading to an inhibition of cell growth and apoptosis in AR-expressing cells.