Single Biggest Cancer Dictionary in the World
What is antisense oligonucleotide GTI-2040?
Pronunciation: /ˈæntiˌsɛns oligonucleotide* gti* tu ˈθaʊzənd ənd ˈfɔrti/
antisense oligonucleotide GTI-2040
Definition
A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo.