Definition

A dietary supplement composed of dried egg yolk powder that is highly enriched in the protein anti-secretory factor (AF), with anti-inflammatory, anti-diarrheal, immunomodulating and chemo-adjuvant activities. Upon intratumoral administration of the AF-enriched egg yolk powder supplement, AF is able to normalize fluid flow by regulating the ion and fluid balance across the cell membranes, and decreases high interstitial fluid pressure (IFP). As elevated IFP presents a barrier to drug uptake and poor perfusion in solid tumors, reducing IFP levels allows for increased uptake and an enhanced effect of chemotherapeutic agents. In addition, AF may be able to modulate the immune system and may have immunomodulatory effects on myeloid cells. It may also modulate the secretion of immunomodulatory agents from tumor cells. In addition, AF may affect the secretion of various pro-inflammatory mediators such as interleukin-6 (IL-6), IL-8, monocyte chemotactic protein-1 (MCP-1; monocyte chemoattractant protein-1; C-C Motif Chemokine Ligand 2; CCL2), macrophage inflammatory protein-1alpha (MIP-1a), and macrophage inflammatory protein-1beta (MIP-1b). AF, a 41 kilodalton (kDa) endogenous and essential protein secreted in plasma and other tissue fluids in mammals, is increased after exposure to bacterial toxins and endogenous triggers of inflammation.