Definition

An agonistic monoclonal antibody directed against tumor necrosis factor receptor 2 (TNFR2; tumor necrosis factor receptor superfamily member 1B; TNFRSF1B), with potential antineoplastic activity. Upon administration, anti-TNFR2 monoclonal antibody BI-1910 targets and binds to TNFR2 expressed on the surface of CD4+ T cells, CD8+ T cells and natural killer (NK) cells in the tumor microenvironment (TME), thereby activating CD4+ T cells, CD8+ T cells and NK cells. This may enhance cytotoxic T-cell- and NK cell-mediated immune responses against tumor cells. TNFR2, a member of the TNFR family of co-stimulatory molecules, plays an important role in T-cell co-stimulation.