Definition

A human immunoglobulin G1 (IgG1) monoclonal antibody targeting certain specific proteins of the human signal-regulatory protein (SIRP) family, with potential immunoregulatory activity. Upon administration, anti-SIRP monoclonal antibody ELA026 targets and binds to SIRP, a cell surface protein expressed on myeloids and T lymphocytes. This depletes pathological myeloids and T lymphocytes that are circulating due to excessive immune activation and inflammation. This eradicates pathological immune cells that are driving inflammation. SIRP is a family of cell surface receptors expressed on various immune cell types. ELA026 does not inhibit the activity of the SIRPalpha/CD47 immune checkpoint.