Single Biggest Cancer Dictionary in the World
What is
anti-PSMA monoclonal antibody MLN591-DM1 immunoconjugate MLN2704
?Pronunciation: /ˈænˌti psma* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi mln* faɪv ˈhənərd ənd ninety-one* dm* wən immunoconjugate* mln* tu ˈθaʊzənd, ˈsɛvən ˈhənərd ənd fɔr/
anti-PSMA monoclonal antibody MLN591-DM1 immunoconjugate MLN2704
Definition
An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death.