Definition

A recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the laminin-related protein netrin-1 (NTN1), with potential antineoplastic activity. Upon administration, anti-NTN1 monoclonal antibody NP137 targets, binds to and neutralizes NTN1, thereby preventing its binding to and activation of NTN1 receptors. By blocking NTN1, NP137 is able to restore apoptosis in tumor cells. This inhibits tumor growth and metastasis. NTN1, overexpressed by a variety of cancers, plays a key role in promoting tumor initiation, progression, proliferation, adhesion, invasion, survival and modulation of tumor+F52:J54 plasticity and the tumor microenvironment (TME).