Definition

A monoclonal antibody targeting the leukocyte immunoglobulin-like receptors B (LILRB) immune checkpoint receptor family, with potential immune checkpoint inhibitory, immunomodulating and antineoplastic activities. Upon administration, anti-LILRB monoclonal antibody ADA-011 targets, binds to and inhibits LILRB family members and their downstream signaling pathways. This may restore immune function and anti-tumor immune responses. The LILRB receptor family is a family of inhibitory immune checkpoint receptors that negatively regulates immune activation and plays an important role in immune evasion. Various LILRBs are expressed on certain types of cancer cells and play a key role in cancer development.