Definition

A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting human guanylate cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin receptor; hSTAR), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GUCY2C CAR T cells target and bind to GUCY2C-expressing tumor cells, thereby inducing selective toxicity in GUCY2C-expressing tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal epithelial cells, is overexpressed on certain tumors of the gastrointestinal (GI) tract.