Definition

An antisense oligonucleotide (ASO) targeting the Forkhead Box P3 (FOXP3) mRNA, with potential immunomodulating and antineoplastic activities. Upon administration, anti-FOXP3 ASO AZD8701 blocks the translation of the FOXP3 protein. Reduction of FOXP3 levels may lessen the immunosuppressive functions of regulatory T cells (Tregs). This may lead to an enhanced immune response and antitumor activity. FOXP3, a transcription factor, plays an important role in the functioning of immunosuppressive Tregs. Tregs are overexpressed in various cancers and are associated with poor response to immune checkpoint inhibitors and poor survival.