Definition

A humanized monoclonal antibody directed against Dickkopf-related protein 1 (Dickkopf-1; DKK1), with potential immunomodulating and antineoplastic activities. Upon administration, anti-DKK1 monoclonal antibody JS015 binds to DKK1 and blocks the interaction between DKK1 and its ligands low-density lipoprotein receptor-related proteins (LRP) 5 and 6. This restores signaling through the Wnt/beta-catenin-dependent (canonical) pathway, and may decrease DKK1-mediated immunosuppressive effects in the tumor microenvironment (TME) and enhance anti-tumor immune responses. DKK1, an inhibitor of the Wnt/beta-catenin-dependent (canonical) signaling pathway, is overexpressed by and dysregulated in some cancers, as well as other diseases including osteoporosis, Alzheimer’s disease and diabetes.