Definition

An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA), linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-CEACAM5 ADC M9140, the anti-CEACAM5 monoclonal antibody moiety targets and binds to CEACAM5 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills CEACAM5-expressing tumor cells through an as of yet undisclosed mechanism. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types.