Single Biggest Cancer Dictionary in the World
What is anti-CD70 monoclonal antibody MDX-1411?
Pronunciation: /ˈænˌti ˈsiˈdi ˈsɛvənti ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi mdx* wən ˈθaʊzənd, fɔr ˈhənərd ənd ˈilɛvən/
anti-CD70 monoclonal antibody MDX-1411
Definition
A glycoengineered, fully human IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Anti-CD70 fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types.