Single Biggest Cancer Dictionary in the World
What is
anti-CD52 monoclonal antibody ALLO-647
?Pronunciation: /ˈænˌti ˈsiˈdi fifty-two* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi allo* sɪks ˈhənərd ənd forty-seven*/
anti-CD52 monoclonal antibody ALLO-647
Definition
A monoclonal antibody directed against the cell surface glycoprotein CD52 (CAMPATH-1 antigen; Cambridge pathology 1 antigen), with potential immunodepleting activity. Upon administration, anti-CD52 monoclonal antibody ALLO-647 selectively targets and binds to CD52, thereby triggering a host immune response that results in the lysis of CD52-positive lymphocytes. This leads to immunodepletion and may prevent graft-versus-host disease (GvHD). CD52 is a glycoprotein expressed on the surface of many immune cells, including essentially all B and T lymphocytes.