Definition

A humanized monoclonal antibody directed against the immune checkpoint cell surface transmembrane glycoprotein CD200 receptor 1 (CD200R1; CD200R; HCRTR2; MOX2R; OX2R; CD200 receptor 1), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-CD200R1 monoclonal antibody 23ME-00610 targets and binds to CD200R1, thereby preventing the interaction of CD200R1 with its ligand CD200, which is highly expressed on certain tumor cell types, and preventing its activity. This inhibits CD200R1-mediated signaling pathways and may re-activate tumor-exhausted T cells and myeloid cells. This may lead to a T-cell mediated anti-tumor immune response and may kill cancer cells. CD200R1 is an inhibitory receptor expressed on T cells and myeloid cells and plays a key role in the maintenance of immune tolerance and immunosuppression.