Single Biggest Cancer Dictionary in the World
What is anti-CD20 monoclonal antibody SCT400?
Pronunciation: /ˈænˌti ˈsiˈdi tˈwɛnti ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi sct* fɔr ˈhənərd/
anti-CD20 monoclonal antibody SCT400
Definition
A chimeric monoclonal antibody directed against human CD20, with potential antineoplastic activity. Anti-CD20 monoclonal antibody SCT400 binds to the B cell-specific cell surface antigen CD20, which triggers an immune response against CD20-positive B-cells, leading to apoptosis. CD20, a non-glycosylated cell surface phosphoprotein, is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies.