Single Biggest Cancer Dictionary in the World
What is anti-CD20 monoclonal antibody PRO131921?
Pronunciation: /ˈænˌti ˈsiˈdi tˈwɛnti ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi proʊ wən ˈhənərd ənd thirty-one* ˈθaʊzənd, naɪn ˈhənərd ənd tˈwɛntiˌwɔn/
anti-CD20 monoclonal antibody PRO131921
Definition
A third-generation, humanized monoclonal antibody directed against human CD20 with potential antineoplastic activity. Anti-CD20 monoclonal antibody PRO131921 specifically binds to the B cell-specific cell surface antigen CD20. This may result in the induction of a B cell-directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) against CD20-expressing B cells leading to B cell apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein which is exclusively expressed on B cells during most stages of B cell development and which is often overexpressed in B-cell malignancies.