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What is anti-CCR8 monoclonal antibody BGB-A3055?
Pronunciation: /ˈænˌti ccr* eɪt ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi bgb* ə θri ˈθaʊzənd ənd fifty-five*/
anti-CCR8 monoclonal antibody BGB-A3055
Definition
A monoclonal antibody directed against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody BGB-A3055 targets and binds to CCR8 on CCR8-positive tumor-infiltrating regulatory T cells (Tregs) in the tumor microenvironment (TME) and prevents chemokine ligand 1 (CCL1)-CCR8-mediated signaling. This may reactivate antitumor immune responses. CCR8 is specifically expressed by tumor-infiltrating Tregs in multiple types of cancer and plays a key role in immunosuppression. High expression is correlated with poor prognosis.