Single Biggest Cancer Dictionary in the World
What is androgen receptor antisense oligonucleotide AZD5312?
Pronunciation: /androgen* riˈsɛptər ˈæntiˌsɛns oligonucleotide* azd* faɪv ˈθaʊzənd, θri ˈhənərd ənd twɛlv/
androgen receptor antisense oligonucleotide AZD5312
Definition
An antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential antineoplastic activity. Upon intravenous administration, AZD5312 hybridizes with AR mRNA, which blocks translation of the AR protein. This both inhibits AR-induced tumor cell growth and promotes apoptosis in AR-overexpressing tumor cells. AR is overexpressed in certain breast and prostate cancers and is involved in tumor cell proliferation and survival.