Single Biggest Cancer Dictionary in the World
What is androgen receptor antagonist BAY 1161116?
Pronunciation: /androgen* riˈsɛptər ænˈtægənəst beɪ wən ˈmɪljən, wən ˈhənərd ənd sixty-one* ˈθaʊzənd, wən ˈhənərd ənd ˈsɪkˈstin/
androgen receptor antagonist BAY 1161116
Definition
An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist BAY 1161116 specifically binds to AR, inhibits AR activation, and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.