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What is allogeneic virus-specific T lymphocytes R-MVST?
Pronunciation: /allogeneic* ˈvaɪrəs spɪˈsɪfɪk ti ˈlɪmfəˌsaɪts ɑr mvst*/
allogeneic virus-specific T lymphocytes R-MVST
Definition
A preparation of allogeneic T lymphocytes generated from partially human leukocyte antigen (HLA)-matched healthy donors or from the original allogeneic hematopoietic stem cell transplantation (HSCT) donor, ex-vivo expanded, and specifically reactive to viruses that may include adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon administration, the allogeneic virus-specific T lymphocytes R-MVST may kill AdV, CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens.