Single Biggest Cancer Dictionary in the World

What is

allogeneic most closely HLA-matched adenovirus-specific cytotoxic T lymphocytes

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Pronunciation: /allogeneic* moʊst ˈkloʊsli hla* mæʧt əˈdɛnəˌvaɪrəs spɪˈsɪfɪk cytotoxic* ti ˈlɪmfəˌsaɪts/

allogeneic most closely HLA-matched adenovirus-specific cytotoxic T lymphocytes

Definition

A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor.